My overall research focuses on digital lifestyle markers obtained through wearable devices and smartphone applications, and their associations with health outcomes. My main research interest is sleep epidemiology and the longitudinal associations between sleep as a behavior and incident disease and mortality outcomes. I am also interested in healthy ageing with the aim of identifying lifestyle choices and lifestyle patterns (measured through wearable devices and daily questionnaires) that may predict healthy longevity. The work in our research group is based on traditional epidemiological methods as well as machine learning and deep learning.

  In addition to my work with SHI, I am affiliated with the Precision Health group, Department of Bioengineering, the University of Tokyo and with the Department of Clinical Sciences Malm? at Lund University in Sweden.

  The main objective of my sleep research is to identify population-level and individual-level associations between sleep as a behavior and adverse health outcomes. Recently, owing to the availability of genetic, proteomic, and metabolomic markers, I am hoping to identify biological pathways that can explain why aberrant sleep patterns in otherwise healthy individuals increase the risk of cardiometabolic diseases and all-cause mortality.

  The primary objectives of our healthy ageing project are to identify lifestyle patterns and biological mechanisms of healthy longevity. We have two healthy ageing cohorts with participants aged 80 years or older: one smaller feasibility study (30 participants followed for 3 months) and one larger cohort study (150 participants followed for at least one year). Collected data includes wearable device data, daily lifestyle questionnaires, clinical biomarkers, clinical tests, and proteomic markers. From 2024, the larger cohort will also have whole genome sequencing and metabolomic markers.

  This project focuses on the prevention of metabolic syndrome using data from Japanese office workers. Data includes annual health check-up information, wearable device data, and questionnaires.

  Please contact me if you have an interest in conducting research that focuses on sleep or digital health, disease prevention with a focus on lifestyle factors, or if you are interested in using exploratory biomarkers to identify potential biological pathways of healthy ageing. I am very much looking forward to hearing from you.

1. Staffini A, Svensson T, Chung UI, Svensson AK.  

   A Disentangled VAE-BiLSTM Model for Heart Rate Anomaly Detection. Bioengineering. 2023;10(6),683. (Impact factor: 4.6)
   Available from: https://doi.org/10.3390/bioengineering10060683

    

    

2. Yamaga Y, Svensson T, Chung UI, Svensson AK. 

   Association between Metabolic Syndrome Status and Daily Physical Activity Measured by a Wearable Device in Japanese Office Workers. Int J Environ Res Public Health. 2023;20(5).
   Available from: http://dx.doi.org/10.3390/ijerph20054315

    

    

3. Shikimoto R, Nozaki S, Sawada N, Shimizu Y, Svensson T, Nakagawa A, Mimura M, Tsugane S.  

   Coping in Mid- to Late Life and Risk of Mild Cognitive Impairment Subtypes and Dementia: A JPHC Saku Mental Health Study. J Alzheimers Dis. 2022;90(3):1085-101.

   Available from: https://doi.org/10.3233/jad-215712

    

    

4. Wilunda C, Abe SK, Svensson T, Sawada N, Tsugane S, Wada K, Nagata C, Kimura T, Tamakoshi A, Sugawara Y, Tsuji I, Ito H, Kitamura T, Sakata R, Mizoue T, Matsuro K, Tanaka K, Lin Y, Inoue M.  

   Sleep duration and risk of cancer incidence and mortality: A pooled analysis of six population-based cohorts in Japan. Int J Cancer. 2022;151(7):1068-80.

   Available from: https://doi.org/10.1002/ijc.34133

    

    

5. Pham H, Svensson T, Chung UI, Svensson AK. 

   Sleep Satisfaction May Modify the Association between Metabolic Syndrome and BMI, Respectively, and Occupational Stress in Japanese Office Workers. Int J Environ Res Public Health. 2022;19(9).

   Available from: https://doi.org/10.3390/ijerph19095095

    

    

6. Staffini A, Fujita K, Svensson AK, Chung UI, Svensson T.  

   Statistical Methods for Item Reduction in a Representative Lifestyle Questionnaire: Pilot Questionnaire Study. Interact J Med Res. 2022;11(1):e28692.
   Available from: https://doi.org/10.2196/28692

    

    

7. Staffini A, Svensson T, Chung UI, Svensson AK.  
   Heart Rate Modeling and Prediction Using Autoregressive Models and Deep Learning. Sensors (Basel). 2021;22(1).

   Available from: https://doi.org/10.3390/s22010034

    

    

8. Svensson T, Sawada N, Mimura M, Nozaki S, Shikimoto R, Tsugane S.  
   Midlife intake of the isoflavone genistein and soy, and the risk of late-life cognitive impairment: the JPHC Saku Mental Health Study. J Epidemiol. 2021.

   Available from: https://doi.org/10.2188/jea.JE20210199

    

    

9. Meguro K^*, Svensson T^*, ChungChung UI, Svensson AK.  

   ^*Both authors contributed equally to the study.
   Associations of Work-related Stress and Total Sleep Time with Cholesterol Levels in an Occupational Cohort of Japanese Office Workers. J Occup Health. 2021;63(1):e12275.

   Available from: https://doi.org/10.1002/1348-9585.12275

    

    

10. Hara K, Kobayashi Y, Tomio J, Ito Y, Svensson T, Ikesu R, Chung UI, Svensson AK.  

    Claims-based algorithms for common chronic conditions were efficiently constructed using machine learning methods. PLoS One. 2021;16(9):e0254394.

    Available from: https://doi.org/10.1371/journal.pone.0254394

     

     

11. Svensson T, Saito E, Svensson AK, Melander O, Orho-Melander M, Mimura M, Rahman S, Sawada N, Koh WP, Shu XO, Tsuji I, Kanemura S, Park SK, Nagata C, Tsugane S, Cai H, Yuan JM, Matsuyama S, Sugawara Y, Wada K, Yoo KY, Chia KS, Boffetta P, Ahsan H, Zheng W, Kang D, Potter JD, Inoue M.  

    Association of Sleep Duration With All- and Major-Cause Mortality Among Adults in Japan, China, Singapore, and Korea. JAMA Netw Open. 2021;4(9):e2122837

    Available from: https://doi.org/10.1001/jamanetworkopen.2021.22837

     

     

12. Ikesu R, Miyawaki A, Svensson AK, Svensson T, Kobayashi Y, Chung UI.  

    Association of managerial position with cardiovascular risk factors: A fixed-effects analysis for Japanese employees. Scandinavian journal of work, environment & health. 2021;47(6):425-34.

    Available from: https://doi.org/10.5271/sjweh.3966

     

     

13. Staffini A, Svensson AK, Chung U-I, Svensson T.  

    An Agent-Based Model of the Local Spread of SARS-CoV-2: Modeling Study. JMIR Med Inform. 2021;9(4):e24192.

    Available from: https://doi.org/10.2196/24192

     

     

14. Aida A, Svensson T, Svensson AK, Urushiyama H, Okushin K, Oguri G, Kubota N, Koike K, Nangaku M, Kadowaki T, Yamauchi T, Chung U-I.  

    Using mHealth to Provide Mobile App Users With Visualization of Health Checkup Data and Educational Videos on Lifestyle-Related Diseases: Methodological Framework for Content Development. JMIR Mhealth Uhealth. 2020;8(10):e20982.

    Available from: https://doi.org/10.2196/20982

     

     

15. Miyashita H, Svensson T, Nakamura M, Svensson AK. 

    The Association Between Hemoglobin Upswing in the Reference Range and SLeep Apnea Syndrome. Sleep and Vigilance. 2020;4(2):205-12.

    Available from: https://doi.org/10.1007/s41782-020-00093-6

     

     

16. Miyashita H, Nakamura M, Svensson AK, Nakamura M, Tokuno S, Chung U-I, Svensson T.

    Association Between Electroencephalogram-Derived Sleep Measures and the Change of Emotional Status Analyzed Using Voice Patterns: Observational Pilot Study. JMIR Form Res. 2020;4(6):e16880.

    Available from: https://doi.org/10.2196/16880

     

     

17. Svensson T, Inoue M, Saito E, Sawada N, Hiroyasu I, Mizoue T, Goto A, Yamaji T, Shimazu T, Iwasaki M, and Tsugane S.  
    The Association Between Habitual Sleep Duration and Mortality According to Sex and Age: The Japan Public Health Center-based Prospective Study. J Epidemiol. 2021;31(2):109-18.

    Available from: https://doi.org/10.2188/jea.JE20190210

     

     

18. Hidaka A, Sawada N, Svensson T, Goto A, Yamaji T, Shimazu T, Iwasaki M, Inoue M, Tsugane S.     

    Family history of cancer and subsequent risk of cancer: A large-scale population-based prospective study in Japan. Int J Cancer. 2020;147(2):331-7.

    Available from: https://doi.org/10.1002/ijc.32724

     

     

19. Svensson T^*, Chung U-i, Tokuno S, Nakamura M, Svensson AK^*.  

    ^*Both authors contributed equally to the study.
    A validation study of a consumer wearable sleep tracker compared to a portable EEG system in naturalistic conditions. J Psychosom Res. 2019;126:109822.

    Available from: https://doi.org/10.1016/j.jpsychores.2019.109822

     

     

20. Tellhed U, Daukantaite D, Maddux R, Svensson T, Melander O. 
    Yogic Breathing and Mindfulness as Stress Coping Mediate Positive Health Outcomes of Yoga. Mindfulness. 2019;10(12):2703-15.

    Available from: https://doi.org/10.1007/s12671-019-01225-4

     

     

21. Svensson T, Sawada N, Mimura M, Nozaki S, Shikimoto R, Tsugane S.  

    The Association between midline serum high-density lipoprotein and mild cognitive impairment and dementia after 19 years of follow-up. Translational psychiatry. 2019;9(1):26.

    Translational psychiatry. 2019;9(1):26.

    Available from: https://doi.org/10.1038/s41398-018-0336-y

     

     

22. Daukantaite D, Tellhed U, Maddux RE, Svensson T, Melander O.  
    Five-week yin yoga-based interventions decreased plasma adrenomedullin and increased psychological health in stressed adults: A randomized controlled trial. PLoS One. 2018;13(7):e0200518.

    Available from: https://doi.org/10.1371/journal.pone.0200518

     

     

23. Hara K, Tomio J, Svensson T, Ohkuma R, Svensson AK, Yamazaki T.   
    Association measures of claims-based algorithms for common chronic conditions were assessed using regularly collected data in Japan. J Clin Epidemiol. 2018;99:84-95.

    Available from: https://doi.org/10.1016/j.jclinepi.2018.03.004

     

     

24. Svensson T^*, Svensson AK^*, Kitlinski M, Almgren P, Engstr?m G, Nilsson J, Orho-Melander M, Nilsson P, Melander O.   ^*Both authors contributed equally to the study.

    Plasma concentration of Caspase-8 is associated with short sleep duration and the risk of incident diabetes mellitus. J Clin Endocrinol Metab. 2018;103(4):1592-1600.

    Available from: https://doi.org/10.1210/jc.2017-02374

     

     

25. Svensson AK^*, Svensson T^*, Kitlinski M, Almgren P, Engstr?m G, Nilsson P, Melander O.   ^*Both authors contributed equally to the study.

    Incident diabetes mellitus may explain the association between sleep duration and incident coronary heart disease. Diabetologia. 2018;61(2):331-41.

    Available from: https://doi.org/10.1007/s00125-017-4464-3

     

     

26. Svensson T, Inoue M, Sawada N, Charvat H, Mimura M, Tsugane S.  

    High serum total cholesterol is associated with suicide mortality in Japanese women. Acta Psychiatr Scand. 2017;136(3):259-68.

    Available from: https://doi.org/10.1111/acps.12758

     

     

27. Svensson T, Kitlinski M, Engstr?m G, Melander O.  

    A genetic risk score for CAD, psychological stress, and their interaction as predictors of CAD, fatal MI, non-fatal MI and cardiovascular death. PLoS One. 2017;12(4):e0176029.

    Available from: https://doi.org/10.1371/journal.pone.0176029

     

     

28. Svensson T, Kitlinski M, Engstr?m G, Melander O.  

    Psychological stress and risk of incident atrial fibrillation in men and women with known atrial fibrillation genetic risk scores. Sci Rep. 2017;7:42613.

    Available from: https://doi.org/10.1038/srep42613

     

     

29. Svensson T, Yamaji T, Budhathoki S, Hidaka A, Iwasaki M, Sawada N, Inoue M, Sasazuki S, Shimazu T, Tsugane S.  

    Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk: the JPHC Study. Sci Rep. 2016;6:36607.

    Available from: https://doi.org/10.1038/srep36607

     

     

30. Svensson T, Inoue M, Sawada N, Yamagishi K, Charvat H, Saito I, Kokubo Y, Iso H, Kawamura N, Shibuya K, Mimura M, Tsugane S.  
    Coping strategies and risk of cardiovascular disease incidence and mortality: the Japan Public Health Center-based prospective Study. European heart journal. 2016;37(11):890-9.

    Available from: https://doi.org/10.1093/eurheartj/ehv724

     

     

31. Svensson T, Inoue M, Sawada N, Charvat H, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Kawamura N, Shibuya K, Mimura M, Tsugane S.  
    Coping strategies and cancer incidence and mortality: The Japan Public Health Center-based prospective study. Cancer Epidemiol. 2016;40:126-33.

    Available from: https://doi.org/10.1016/j.canep.2015.12.003

     

     

32. Melander O, Orho-Melander M, Manjer J, Svensson T, Almgren P, Nilsson PM, Engstr?m G, Hedblad B, Borgquist S, Hartmann O, Struck J, Bergmann A, Belting M.  　

    Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.

    J Clin Oncol. 2015;33(24):2632-8.

    Available from: https://doi.org/10.1200/jco.2014.59.7682

     

     

33. Svensson T, Inoue M, Sawada N, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Ikeda A, Kawamura N, Mimura M, Tsugane S.  　

    The association between complete and partial non-response to psychosocial questions and suicide: the JPHC Study. Eur J Public Health. 2015;25(3):424-30.

    Available from: https://doi.org/10.1093/eurpub/cku209

     

     

34. Svensson T, Inoue M, Charvat H, Sawada N, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Ikeda A, Kawamura N, Mimura M, Tsugane S.  　

    Coping behaviors and suicide in the middle-aged and older Japanese general population: the Japan Public Health Center-based Prospective Study. Ann Epidemiol. 2014;24(3):199-205.

    Available from: https://doi.org/10.1016/j.annepidem.2013.12.006

     

     

35. Bergkvist D, Hekmat K, Svensson T, Dahlberg L.  

    Obesity in orthopedic patients. Surg Obes Relat Dis. 2009;5(6):670-2

    Available from: https://doi.org/10.1016/j.soard.2009.05.014

     

Chee MK, Svensson T.

Benefits of adhering to sleep duration recommendations: Reframing an enduring issue. Sleep Med. 2022;101:373-4.
Available from: https://doi.org/10.1016/j.sleep.2022.11.024

Aida A, Svensson T, Svensson AK, Chung U-I, Yamauchi T.

eHealth Delivery of Educational Content Using Selected Visual Methods to Improve Health Literacy on Lifestyle-Related Diseases: Literature Review JMIR Mhealth Uhealth. 2020;8(12):e18316.

Available from: https://doi.org/10.2196/18316